“Cannabinoids may have another therapeutic benefit in managing chronic pain, with regard to sleep. Not only does normalized sleep improve pain relief and mood disorders associated with both poor pain control and poor sleep patterns, but there is significant risk of sleep-disordered breathing associated with central nervous system (CNS) drugs used to treat chronic pain. Opioid analgesics are most problematic, especially if combined with other CNS depressants such as benzodiazepines. It has been reported that cannabinoids suppress sleep-related apnea. This is an important area for further research and clinical application both in sleep and pain medicine.”
CBD (Cannabidiol) as potential anticancer drug
Collectively, the non-psychoactive plant-derived cannabinoid CBD exhibits pro-apoptotic and anti-proliferative actions in different types of tumours and may also exert anti-migratory, anti-invasive, anti-metastatic and perhaps anti-angiogenic properties. On the basis of these results, evidence is emerging to suggest that CBD is a potent inhibitor of both cancer growth and spread.
Endocannabinoid System and Neurodegenerative disease
“Several lines of evidence suggest a primary function of endocannabinoids, CBRs and other components of EC system in the degenerative process. Various investigators using a variety of preclinical models have discovered the therapeutic intervention strategies modulating EC system. Furthermore, current approaches to the development of novel therapeutic strategies for neurodegenerative diseases have focused not only on their neuroprotective properties but also on alleviating symptoms of the neurodegenerative diseases. These approaches are based on the well-characterized role of cannabinoids that have the ability to control both anti-inflammatory and neuroprotective functions. Therefore, the use of CB2R agonists and CB1R antagonists endeavor an interesting, unique and potential therapeutic advance for neurodegenerative disorders.”
